Pathogenesis, histology, and transplantability of urinary bladder carcinomas induced in albino rats by oral administration of N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide. | Semantic Scholar (2024)

Electron microscopy shows microvillous transformation of the luminal plasma membrane and appearance of a thick fluffy cell coat (glycocalyx) which is explained by an altered function of the Golgi complex occurring during malignancy and leading to a loss of the specific discoid vesicles of the urothelial cells.

A systemic lymphoreticular response involving the spleen and lymph nodes was seen in a majority of the rats, and several rats had edema, hemorrhage, and partial destruction of the adrenal gland.

No significant statistical relationship could be ascertained between tumors stage and grade or between grade and weight, but a correlation was established between tumor stage and weight.

RF, BALB/c, and C3H female mice, regarded as having a low incidence of spontaneous leukemia, were as susceptible to the leukemogenic effect of NFTA as were Swiss mice.

Chemotherapeutic agents were evaluated for effect on the development of urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in male Wistar strain rats, however, adriamycin (ADM), mitomycin C (MMC), neocarsinostatin (NCS), cyclophosphamide (CPM) and bleomycin (BLM) were not effective.

NAR showed lower susceptibility than control SD to induction of bladder cancer by FANFT, and proliferative lesions of the bladder epithelium were found in 16 of 24 SD but in only 4 of 18 NAR.

These animal systems appear useful in providing opportunities for investigations relevant to human bladder cancer, and the guinea pig appeared resistant to the bladder oncogen icity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]fonmamide.

The combined 3- and 6-month data indicate that excreted carcinogen in the urine influences progression of the preinvasive lesions more than urine alone or systemic carcinogen alone.

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The first nitrofuran derivative which has been found to be a bladder carcinogen, and the compound appears to be one of the most effective bladder carcinogens for this species.

The carcinogenic property of 2-acetylaminofluorene was first described by Wilson and his associates (9) in 1941 and found to be innocuous when injected subcutaneously, and surmising that the subcutaneous tissues could not split off the acety] group.

The target organ response to estradiol was comparable to that generally obtained in rats receiving this substance alone but that to testosterone was almost nonexistent in many instances and minimal in others.

This paper describes the production of distant tumors by 2-amino-flourene and 2-acetyl-AMino-fluorene in 109 2 month old albino rats of Wistar strain and finds that the presence of ovaries is an important factor for the mammary carcinogenesis in these experiments.

No reliable experimental evidence that either aniline, toluidines, or xylidines are carcinogenic is found, although a variety of other aromatic compounds have been suspected.

The effects of feeding -the amine to dogs are described and tumours of the liver, intestine, and mammary gland were found following the repeated subcutaneous injection of 4-aminodiphenyl in arachis oil.

The histologic appearance of the neoplasms and other parameters of the study suggest that this experiment has resulted in the production of lesions that are indistinguishable from the naturally occurring bovine bladder tumors which are a common feature of bovines enzootic hematuria.

Urine from cattle fed fresh and dried bracken fern for more than 2 years and urine from control cattle was extracted with ethyl acetate and divided into nonacidic and acidic fractions, and the only group of animals with a tumor incidence which was significantly different from the control mice exposed to pure cholesterol were the mice exposure to the acidic fraction of the urine of cattle fed brackan fern.

The results of the investigation of the behavior in laboratory animals of benzidine and also of groups of compounds that are either encountered during its manufacture (azoxybenzene, hydrazobenzene and benzidine sulfate) or are closely allied to it chem-

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